Human SVH (ARMC10) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ARMC10
Locus ID	83787
Kit Components	GA113267G1, SVH gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113267G2, SVH gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113267G3, SVH gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001161009, NM_001161010, NM_001161011, NM_001161012, NM_001161013, NM_031905
Synonyms	PNAS-112; PNAS112; PSEC0198; SVH
Summary	This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]

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