Human PAMM (FAM213A) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PRXL2A
Locus ID	84293
Kit Components	GA113489G1, PAMM gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113489G2, PAMM gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113489G3, PAMM gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001136047, NM_001243778, NM_001243779, NM_001243780, NM_001243781, NM_001243782, NM_032333, NR_024572
Synonyms	C10orf58; PAMM
Summary	Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).[UniProtKB/Swiss-Prot Function]

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