Human CLACP (COL25A1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	COL25A1
Locus ID	84570
Kit Components	GA113601G1, CLACP gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113601G2, CLACP gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113601G3, CLACP gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001256074, NM_032518, NM_198721, NR_045756
Synonyms	AMY; CFEOM5; CLAC; CLAC-P; CLACP
Summary	This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

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