Human GLYR1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GLYR1
Locus ID	84656
Kit Components	GA113633G1, GLYR1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113633G2, GLYR1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113633G3, GLYR1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001308096, NM_001324096, NM_001324097, NM_001324098, NM_032569, NR_136695, NR_136696, NR_136697, NR_136698, NR_136699, NR_136700
Synonyms	BM045; HIBDL; N-PAC; NP60
Summary	Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity (PubMed:23260659). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20850016). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664).[UniProtKB/Swiss-Prot Function]

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