Human XRCC6BP1 (ATP23) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ATP23
Locus ID	91419
Kit Components	GA114113G1, XRCC6BP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114113G2, XRCC6BP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114113G3, XRCC6BP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001320408, NM_001320409, NM_001320410, NM_033276
Synonyms	KUB3; XRCC6BP1
Summary	The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

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