Human TDRD12 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TDRD12
Locus ID	91646
Kit Components	GA114134G1, TDRD12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114134G2, TDRD12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114134G3, TDRD12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001015890, NM_001110822, NM_001366102
Synonyms	ECAT8
Summary	Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.[UniProtKB/Swiss-Prot Function]

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