Human SPSB4 activation kit by CRISPRa
CAT#: GA114212
SPSB4 CRISPRa kit - CRISPR gene activation of human splA/ryanodine receptor domain and SOCS box containing 4
CNY 12255.00
CNY 2400.00
CNY 3990.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | SPSB4 |
Locus ID | 92369 |
Kit Components | GA114212G1, SPSB4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114212G2, SPSB4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114212G3, SPSB4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Reference Data | |
RefSeq | NM_080862 |
Synonyms | SSB-4; SSB4 |
Summary | Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21199876, PubMed:15601820). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 (PubMed:28931592). Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 (PubMed:26392558).[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN403566 | SPSB4 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8680.00 |