Human SPSB4 activation kit by CRISPRa

CAT#: GA114212

SPSB4 CRISPRa kit - CRISPR gene activation of human splA/ryanodine receptor domain and SOCS box containing 4



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CNY 12255.00


货期*
4周

规格
    • 1 kit

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SPSB4 (Myc-DDK-tagged)-Human splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4)
    • 10 ug

CNY 2400.00
CNY 3990.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol SPSB4
Locus ID 92369
Kit Components

GA114212G1, SPSB4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA114212G2, SPSB4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA114212G3, SPSB4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Reference Data
RefSeq NM_080862
Synonyms SSB-4; SSB4
Summary Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21199876, PubMed:15601820). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 (PubMed:28931592). Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 (PubMed:26392558).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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