Human DECTIN 2 (CLEC6A) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CLEC6A
Locus ID	93978
Kit Components	GA114307G1, DECTIN 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114307G2, DECTIN 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114307G3, DECTIN 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001007033, NM_001317999
Synonyms	CLEC4N; CLECSF10
Summary	The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

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