Human DPH4 (DNAJC24) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DNAJC24
Locus ID	120526
Kit Components	GA114720G1, DPH4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114720G2, DPH4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114720G3, DPH4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_181706
Synonyms	DPH4; JJJ3; ZCSL3
Summary	Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]

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