Human PPIL5 (LRR1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LRR1
Locus ID	122769
Kit Components	GA114786G1, PPIL5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114786G2, PPIL5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114786G3, PPIL5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_152329, NM_203466, NM_203467, NR_037792, NR_037793
Synonyms	4-1BBLRR; LRR-1; PPIL5
Summary	The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

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