Human C2orf60 (TYW5) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TYW5
Locus ID	129450
Kit Components	GA115082G1, C2orf60 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115082G2, C2orf60 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115082G3, C2orf60 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001039693, NM_152382, NR_004862, NR_109905, NR_109906, NR_109907
Synonyms	C2orf60; hTYW5
Summary	tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.[UniProtKB/Swiss-Prot Function]

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