Human IBRDC1 (RNF217) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RNF217
Locus ID	154214
Kit Components	GA115888G1, IBRDC1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115888G2, IBRDC1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115888G3, IBRDC1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001286398, NM_152553, NR_104440, NR_136734
Synonyms	C6orf172; dJ84N20.1; IBRDC1; OSTL
Summary	This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

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