Human NLRP11 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NLRP11
Locus ID	204801
Kit Components	GA116457G1, NLRP11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116457G2, NLRP11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116457G3, NLRP11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001297743, NM_145007
Synonyms	CLR19.6; NALP11; NOD17; PAN10; PYPAF6; PYPAF7
Summary	This gene is a member of the the NOD-like receptor protein (NLRP) gene family and encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene has been shown to regulate caspases in the proinflammatory signal transduction pathway and, based on studies of other members of the NLRP gene family with similar domain structure, is predicted to form part of the multiprotein inflammasome complex. Alternative splicing produces multiple transcript variants encoding distince isoforms. [provided by RefSeq, May 2017]

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