Human POLDIP1 (KCTD13) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	KCTD13
Locus ID	253980
Kit Components	GA116763G1, POLDIP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116763G2, POLDIP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116763G3, POLDIP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_178863, NR_110933
Synonyms	BACURD1; FKSG86; hBACURD1; PDIP1; POLDIP1
Summary	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:19782033). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome (PubMed:19782033) Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity).[UniProtKB/Swiss-Prot Function]

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