Human C15orf38 (ARPIN) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ARPIN
Locus ID	348110
Kit Components	GA117673G1, C15orf38 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA117673G2, C15orf38 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA117673G3, C15orf38 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001282380, NM_182616
Synonyms	C15orf38
Summary	Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.[UniProtKB/Swiss-Prot Function]

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