Mouse Atp6v1a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Atp6v1a
Locus ID	11964
Kit Components	GA200332G1, Atp6v1a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200332G2, Atp6v1a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200332G3, Atp6v1a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_007508, NM_001358203, NM_001358204
Synonyms	AI647066; Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2
Summary	Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity.[UniProtKB/Swiss-Prot Function]

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