Mouse Bard1 activation kit by CRISPRa
CAT#: GA200368
Bard1 CRISPRa kit - CRISPR gene activation of mouse BRCA1 associated RING domain 1
CNY 12255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Bard1 |
Locus ID | 12021 |
Kit Components | GA200368G1, Bard1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200368G2, Bard1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200368G3, Bard1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Reference Data | |
RefSeq | NM_007525 |
Synonyms | ENSMUSG00000060893; ENSMUSG00000073653 |
Summary | E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN501977 | Bard1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
CNY 8680.00 |