Mouse Casp14 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Casp14
Locus ID	12365
Kit Components	GA200536G1, Casp14 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200536G2, Casp14 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200536G3, Casp14 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_009809
Synonyms	MICE; mini-ICE
Summary	Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification (PubMed:18156206). Regulates maturation of the epidermis by proteolytically processing filaggrin (PubMed:21654840). In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis (PubMed:24872419). May be involved in retinal pigment epithelium cell barrier function (By similarity).[UniProtKB/Swiss-Prot Function]

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