Mouse Casp8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Casp8
Locus ID	12370
Kit Components	GA200541G1, Casp8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200541G2, Casp8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200541G3, Casp8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001080126, NM_001277926, NM_009812
Synonyms	CASP-8; FLICE; MACH; Mch5
Summary	This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]

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