Mouse Cbx5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cbx5
Locus ID	12419
Kit Components	GA200572G1, Cbx5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200572G2, Cbx5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200572G3, Cbx5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001076789, NM_001110216, NM_007626, NM_001358950
Synonyms	2610029O15Rik; C75991; HP1; Hp1a; Hp1alpha
Summary	Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity).[UniProtKB/Swiss-Prot Function]

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