Mouse Cdkn2c activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cdkn2c
Locus ID	12580
Kit Components	GA200681G1, Cdkn2c gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200681G2, Cdkn2c gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200681G3, Cdkn2c gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001301368, NM_007671
Synonyms	C77269; INK4c; p18; p18-INK4c; p18-INK6; p18INK4c
Summary	The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase (cdk) inhibitors, and contains five ankyrin repeats. This protein interacts with both Cdk4 and Cdk6 to inhibit their kinase activities, and prevent their interactions with D-type cyclins, thereby negatively regulating cell division. This gene is differentially expressed in a variety of tissues, and is cell cycle regulated. Deletion of this gene can lead to tumor growth. Maximal expression is observed at the G2/M phase. Alternative splicing and promoter usage results in multiple transript variants. [provided by RefSeq, Aug 2014]

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