Mouse Cflar activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cflar
Locus ID	12633
Kit Components	GA200707G1, Cflar gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200707G2, Cflar gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200707G3, Cflar gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001289704, NM_001293804, NM_001293805, NM_009805, NM_207653, NR_110361, NM_001355056, NR_149255, NR_149256, NR_149257, NR_149258
Synonyms	2310024N18Rik; A430105C05Rik; c-Flip; Cash; Casper; CLARP; ENSMUSG00000072980; FLAME; FLAME-1; Flip
Summary	Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity).[UniProtKB/Swiss-Prot Function]

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