Mouse Cplx2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cplx2
Locus ID	12890
Kit Components	GA200856G1, Cplx2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200856G2, Cplx2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200856G3, Cplx2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_009946, NM_001362218
Synonyms	921-L; AI413745; AW492120
Summary	Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:11163241, PubMed:23345244). Also involved in mast cell exocytosis (PubMed:11163241). Although not essential for development, seems critical for the acquisition of higher cognitive functions in the adult brain (PubMed:12915444).[UniProtKB/Swiss-Prot Function]

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