Mouse S1pr1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	S1pr1
Locus ID	13609
Kit Components	GA201174G1, S1pr1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201174G2, S1pr1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201174G3, S1pr1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_007901
Synonyms	AI849002; Edg1; Lpb1; S1p; S1p1
Summary	This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans. [provided by RefSeq, Jan 2010]

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