Mouse Elk4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Elk4
Locus ID	13714
Kit Components	GA201225G1, Elk4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201225G2, Elk4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201225G3, Elk4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_007923
Synonyms	2310011G17Rik; A130026I01Rik; BB162516; SAP-1; Sap1
Summary	Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously (By similarity).[UniProtKB/Swiss-Prot Function]

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