Mouse Lpin1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Lpin1
Locus ID	14245
Kit Components	GA201442G1, Lpin1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201442G2, Lpin1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201442G3, Lpin1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001130412, NM_015763, NM_172950, NM_001355598
Synonyms	4631420P06; fld; Kiaa0188; Lipin1; mKIAA0188
Summary	Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis. Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. Isoform 1 is recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol.[UniProtKB/Swiss-Prot Function]

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