Mouse Folr1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Folr1
Locus ID	14275
Kit Components	GA201461G1, Folr1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201461G2, Folr1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201461G3, Folr1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001252552, NM_001252553, NM_001252554, NM_008034
Synonyms	FBP1; Folbp-1; Folbp1
Summary	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption.[UniProtKB/Swiss-Prot Function]

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