Mouse Gcsam activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Gcsam
Locus ID	14525
Kit Components	GA201565G1, Gcsam gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201565G2, Gcsam gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201565G3, Gcsam gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001159297, NM_008099
Synonyms	Gcet; Gcet2; M17; M17-L
Summary	Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.[UniProtKB/Swiss-Prot Function]

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