Mouse Ptgdr2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ptgdr2
Locus ID	14764
Kit Components	GA201706G1, Ptgdr2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201706G2, Ptgdr2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201706G3, Ptgdr2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_009962
Synonyms	Crth2; Gpr44; Grp45
Summary	Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity).[UniProtKB/Swiss-Prot Function]

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