Mouse Gtf2i activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Gtf2i
Locus ID	14886
Kit Components	GA201775G1, Gtf2i gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201775G2, Gtf2i gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201775G3, Gtf2i gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001080746, NM_001080747, NM_001080748, NM_001080749, NM_010365, NM_001359062, NM_001359063, NM_001359064, NM_001359065, NM_001359066, NM_001359067
Synonyms	6030441I21Rik; BAP-135; Diws1t; GtfII-I; Spin; TFII-I; WBSCR6
Summary	Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box (By similarity). Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.[UniProtKB/Swiss-Prot Function]

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