Mouse Ins2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ins2
Locus ID	16334
Kit Components	GA202175G1, Ins2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202175G2, Ins2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202175G3, Ins2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001185083, NM_001185084, NM_008387
Synonyms	AA986540; Ins-2; InsII; Mody; Mody4
Summary	This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

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