Mouse Kcnk2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Kcnk2
Locus ID	16526
Kit Components	GA202276G1, Kcnk2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202276G2, Kcnk2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202276G3, Kcnk2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001159850, NM_001281847, NM_001281848, NM_010607, NR_027627, NM_001357119
Synonyms	A430027H14Rik; AI848635; TREK-1
Summary	Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2 (PubMed:24496152). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (PubMed:24496152).[UniProtKB/Swiss-Prot Function]

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