Mouse Lnx1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Lnx1
Locus ID	16924
Kit Components	GA202481G1, Lnx1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202481G2, Lnx1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202481G3, Lnx1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001159577, NM_001159578, NM_001159579, NM_001159580, NM_010727, NM_001359074
Synonyms	Lnx
Summary	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.[UniProtKB/Swiss-Prot Function]

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