Mouse Nprl3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nprl3
Locus ID	17168
Kit Components	GA202573G1, Nprl3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202573G2, Nprl3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202573G3, Nprl3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001284359, NM_001284360, NM_181569, NR_104306
Synonyms	Aag; CGTHBA; HS-26; HS-40; m(alpha)RE; Mare; Phg; Prox1
Summary	As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.[UniProtKB/Swiss-Prot Function]

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