Mouse Mas1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mas1
Locus ID	17171
Kit Components	GA202575G1, Mas1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202575G2, Mas1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202575G3, Mas1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_008552
Synonyms	Mas-1; Mgra
Summary	Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 (By similarity). Receptor for angiotensin 1-7.[UniProtKB/Swiss-Prot Function]

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