Mouse Max activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Max
Locus ID	17187
Kit Components	GA202587G1, Max gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202587G2, Max gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202587G3, Max gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001146176, NM_008558, NM_001361663, NM_001361664
Synonyms	AA960152; AI875693; bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8
Summary	Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. CpG methylation of the recognition site greatly inhibits DNA binding, suggesting that DNA methylation may regulate the MYC:MAX complex in vivo. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements (By similarity).[UniProtKB/Swiss-Prot Function]

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