Mouse Mdm4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mdm4
Locus ID	17248
Kit Components	GA202622G1, Mdm4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202622G2, Mdm4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202622G3, Mdm4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001302801, NM_001302802, NM_001302803, NM_001302804, NM_008575, NR_126506
Synonyms	4933417N07Rik; AA414968; AL023055; AU018793; AU021806; C85810; Mdmx
Summary	This gene encodes a protein that has been shown to negatively regulate the activity of the tumor suppressor protein p53. Homozygous knockout mice exhibit embryonic lethality as a result of p53-dependent apoptosis and cell cycle arrest. Amplification of this gene or overexpression of the encoded protein has been linked to a range of human cancers. A pseudogene has been identified on the X chromosome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]

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