Mouse Mlf1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mlf1
Locus ID	17349
Kit Components	GA202666G1, Mlf1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202666G2, Mlf1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202666G3, Mlf1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001039543, NM_010801
Synonyms	HLS7
Summary	Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.[UniProtKB/Swiss-Prot Function]

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