Mouse Msx2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Msx2
Locus ID	17702
Kit Components	GA202729G1, Msx2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202729G2, Msx2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202729G3, Msx2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_013601
Synonyms	BB122635; Hox-8; Hox8; Hox8.1
Summary	Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.[UniProtKB/Swiss-Prot Function]

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