Mouse Nfe2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nfe2
Locus ID	18022
Kit Components	GA202874G1, Nfe2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202874G2, Nfe2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202874G3, Nfe2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001302338, NM_001302339, NM_001302340, NM_001302341, NM_001302343, NM_008685
Synonyms	NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2
Summary	Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.[UniProtKB/Swiss-Prot Function]

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