Mouse Npc1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Npc1
Locus ID	18145
Kit Components	GA202945G1, Npc1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202945G2, Npc1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202945G3, Npc1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_008720
Synonyms	A430089E03Rik; C85354; D18Ertd139e; D18Ertd723e; lcsd; nmf164; spm
Summary	Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:21896731, PubMed:22048958, PubMed:27551080). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (By similarity). May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).[UniProtKB/Swiss-Prot Function]

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