Mouse Orc2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Orc2
Locus ID	18393
Kit Components	GA203055G1, Orc2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203055G2, Orc2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203055G3, Orc2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001025378, NM_001271526, NM_008765
Synonyms	AU041563; Orc2l
Summary	Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3 (By similarity).[UniProtKB/Swiss-Prot Function]

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