Mouse Pappa activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pappa
Locus ID	18491
Kit Components	GA203098G1, Pappa gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203098G2, Pappa gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203098G3, Pappa gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_021362
Synonyms	8430414N03Rik; IGFBP-4ase; PAG1; PAPP-A
Summary	Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected.[UniProtKB/Swiss-Prot Function]

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