Mouse Pfkl activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pfkl
Locus ID	18641
Kit Components	GA203188G1, Pfkl gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203188G2, Pfkl gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203188G3, Pfkl gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_008826, NM_001358793
Synonyms	AA407869; ATP-PFK; PFK-L
Summary	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (PubMed:26194095).[UniProtKB/Swiss-Prot Function]

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