Mouse Plaa activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Plaa
Locus ID	18786
Kit Components	GA203269G1, Plaa gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203269G2, Plaa gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203269G3, Plaa gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_172695
Synonyms	2410007N06; AI536418; AU018445; AW208417; D4Ertd618e; PLA2P; PLAP; Ufd3
Summary	Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (By similarity). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (PubMed:28413018). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (By similarity). Plays a role in cerebellar Purkinje cell development (PubMed:28413018). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:28007986).[UniProtKB/Swiss-Prot Function]

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