Mouse Ptpn12 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ptpn12
Locus ID	19248
Kit Components	GA203474G1, Ptpn12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203474G2, Ptpn12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203474G3, Ptpn12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_011203, NM_001356591, NM_001356590, NM_001356592
Synonyms	P19-PTP; PTP-P19; PTP-PEST; PTPG1
Summary	Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:17070019). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (By similarity).[UniProtKB/Swiss-Prot Function]

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