Mouse Ptpn14 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ptpn14
Locus ID	19250
Kit Components	GA203476G1, Ptpn14 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203476G2, Ptpn14 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203476G3, Ptpn14 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_008976, NM_001033287
Synonyms	C130080N23Rik; OTTMUSG00000022087; PTP36
Summary	Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.[UniProtKB/Swiss-Prot Function]

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