Mouse Scn5a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Scn5a
Locus ID	20271
Kit Components	GA203783G1, Scn5a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203783G2, Scn5a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203783G3, Scn5a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001253860, NM_021544
Synonyms	mH1; Nav1.5; Nav1.5c; SkM1; SkM2
Summary	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:11834499, PubMed:23420830). It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels (By similarity).[UniProtKB/Swiss-Prot Function]

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