Mouse Scn8a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Scn8a
Locus ID	20273
Kit Components	GA203785G1, Scn8a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203785G2, Scn8a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203785G3, Scn8a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001077499, NM_011323
Synonyms	AI853486; C630029C19Rik; dmu; med; mnd-2; mnd2; NaCh6; Nav1.6; nmf2; nmf58; nmf335; nur14; seal
Summary	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages, isoform 5 may participate in the control of podosome and invadopodia formation.[UniProtKB/Swiss-Prot Function]

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