Mouse Slc1a2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Slc1a2
Locus ID	20511
Kit Components	GA203940G1, Slc1a2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203940G2, Slc1a2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203940G3, Slc1a2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001077514, NM_001077515, NM_011393, NM_001361018
Synonyms	1700091C19Rik; 2900019G14Rik; AI159670; Eaat2; GLT-1; GLT1; MGLT1
Summary	Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7698742, PubMed:7557442, PubMed:9373176). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (PubMed:9180080).[UniProtKB/Swiss-Prot Function]

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